{"id":7029,"date":"2023-01-19T14:49:52","date_gmt":"2023-01-19T14:49:52","guid":{"rendered":"https:\/\/polymer.bas.bg\/projects\/national-science-fund\/%d0%bd%d0%be%d0%b2%d0%b8-%d0%b5%d0%bb%d0%b5%d0%ba%d1%82%d1%80%d0%be%d0%be%d0%b2%d0%bb%d0%b0%d0%ba%d0%bd%d0%b5%d0%bd%d0%b8-%d0%bf%d0%be%d0%bb%d0%b8%d0%bc%d0%b5%d1%80%d0%bd%d0%b8-%d0%bc%d0%b0%d1%82\/"},"modified":"2023-07-28T11:45:10","modified_gmt":"2023-07-28T11:45:10","slug":"%d0%bd%d0%be%d0%b2%d0%b8-%d0%b5%d0%bb%d0%b5%d0%ba%d1%82%d1%80%d0%be%d0%be%d0%b2%d0%bb%d0%b0%d0%ba%d0%bd%d0%b5%d0%bd%d0%b8-%d0%bf%d0%be%d0%bb%d0%b8%d0%bc%d0%b5%d1%80%d0%bd%d0%b8-%d0%bc%d0%b0%d1%82","status":"publish","type":"page","link":"https:\/\/polymer.bas.bg\/en\/projects\/national-science-fund\/%d0%bd%d0%be%d0%b2%d0%b8-%d0%b5%d0%bb%d0%b5%d0%ba%d1%82%d1%80%d0%be%d0%be%d0%b2%d0%bb%d0%b0%d0%ba%d0%bd%d0%b5%d0%bd%d0%b8-%d0%bf%d0%be%d0%bb%d0%b8%d0%bc%d0%b5%d1%80%d0%bd%d0%b8-%d0%bc%d0%b0%d1%82\/","title":{"rendered":"New Electrospun Polymeric Materials Containing Natural Biologically Active Compounds: Preparation and Properties"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7029\" class=\"elementor elementor-7029 elementor-1931\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-617b4bc elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"617b4bc\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d496f7f\" data-id=\"d496f7f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c6d2dce elementor-widget elementor-widget-image\" data-id=\"c6d2dce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"592\" height=\"120\" src=\"https:\/\/polymer.bas.bg\/wp-content\/uploads\/2022\/10\/fni-logo.png\" class=\"attachment-large size-large wp-image-4521\" alt=\"\" srcset=\"https:\/\/polymer.bas.bg\/wp-content\/uploads\/2022\/10\/fni-logo.png 592w, https:\/\/polymer.bas.bg\/wp-content\/uploads\/2022\/10\/fni-logo-300x61.png 300w\" sizes=\"(max-width: 592px) 100vw, 592px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b000185 elementor-widget elementor-widget-heading\" data-id=\"b000185\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">New Electrospun Polymeric Materials Containing Natural Biologically Active Compounds: Preparation and Properties <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-096ab83 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"096ab83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-000c349 elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"000c349\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9390a35\" data-id=\"9390a35\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7f7de4d elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7f7de4d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-9367aaf\" data-id=\"9367aaf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-be3deaa elementor-widget elementor-widget-heading\" data-id=\"be3deaa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Coordinator:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff3f3c4 elementor-widget elementor-widget-text-editor\" data-id=\"ff3f3c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Prof. Nevenka Emanuilova Manolova, DSc<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee2d9eb elementor-widget elementor-widget-heading\" data-id=\"ee2d9eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Base organization:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a21c33 elementor-widget elementor-widget-text-editor\" data-id=\"7a21c33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Institute of Polymers,\u00a0<\/em><em>Bulgarian Academy of Sciences<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a876ca7 elementor-widget elementor-widget-heading\" data-id=\"a876ca7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Partner  organizations:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fea9ce5 elementor-widget elementor-widget-text-editor\" data-id=\"fea9ce5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Faculty of Pharmacy &#8211; Medical University \u2013 Sofia<br \/><\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d32ef90 elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"d32ef90\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-c721e5a\" data-id=\"c721e5a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c16f9aa elementor-widget elementor-widget-heading\" data-id=\"c16f9aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Duration:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fa6929f elementor-widget elementor-widget-text-editor\" data-id=\"fa6929f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>December 2014 \u2013 December 2017<br \/><\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-664de48 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"664de48\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-088de00\" data-id=\"088de00\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4987f24 elementor-widget elementor-widget-heading\" data-id=\"4987f24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Abstract<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-290360d elementor-widget elementor-widget-text-editor\" data-id=\"290360d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Novel advanced materials from biocompatible bio-based polymers such as poly(lactic acid), poly(3-hydroxybutyrate) and polysaccharides containing bioactive compounds of plant origin such as curcumin, caffeic acid and its esters are being developed. Obtaining novel micro- and nanofibrous materials with antimicrobial, antioxidant and\/or antitumor activity is aimed at. The new materials are being prepared by electrospinning or by electrospinning in conjunction with electrospraying \u2013 cutting-edge technologies, using equipment developed at the Laboratory of Bioactive Polymers. The possibilities to increase the stability of the embedded biologically active substance, and to find original approaches to the modulation of its release profile by appropriate composition selection and targeted design of the materials are examined. The biological behavior of the novel materials is assessed in vitro in order to estimate their prospects in wound healing and in antineoplastic therapy, which is of great social and economic importance. The expertise of internationally recognized highly qualified team members and the availability of advanced scientific equipment create prerequisites for high-level interdisciplinary research and acquisition of new knowledge. The young scientists and PhD students included in the team will gain knowledge in the fields of new polymer materials, nanotechnology and nanomedicine. Up to now, the results have been published as follows:<br \/>1. G. Yakub, A. Toncheva, N. Manolova, I. Rashkov, D. Danchev, V. Kussovski, Electrospun polylactide-based materials for curcumin release: photostability, antimicrobial activity, and anticoagulant effect, J. Appl. Polym. Sci., 133 (5), 2016, DOI: 10.1002\/app.42940<br \/>2. M. Ignatova, N. Manolova, I. Rashkov, N. Markova, R. Toshkova, A. Georgieva, E. Nikolova, Poly(3-hydroxybutyrate)\/caffeic acid electrospun fibrous materials coated with polyelectrolyte complex and their antibacterial activity and in vitro antitumor effect against HeLa cells, Mater. Sci. Eng. C: Mater. Biol. Appl., 65: 379-392 (2016) DOI:10.1016\/j.msec.2016.04.060<br \/>3. M. Ignatova, N. Manolova, I. Rashkov, N. Markova, Quaternized chitosan\/\u03ba-carrageenan\/caffeic acid-coated fibrous materials: Preparation, antibacterial and antioxidant activity, Int. J. Pharm., 513 (1-2): 528-537 (2016) DOI: 10.1016\/j.ijpharm.2016.09.062<br \/>4. Y. Ilieva, K. Kaloyanov, D. Yosifov, M. Zaharieva, P. Donchev, G. Yakub, A. Toncheva, I. Rashkov, N. Manolova, I. Zhelezova, D. Momekova, G. Momekov, H. Najdenski, S. Konstantinov, Curcumin loaded biocompatible electrospun polymer mats for the treatment of CTCL skin lesions, Br. J. Haematol., 173: 75 (2016)<br \/>5. P. Tsekova, M. Spasova, N. Manolova, N. Markova, I. Rashkov, Electrospun curcumin-loaded cellulose acetate\/polyvinylpirrolidone fibrous materials with complex architecture and antibacterial activity, Mater. Sci. Eng. C: Mater. Biol. Appl., 73: 206\u2013214(2017), DOI: 10.1016\/j.msec.2016.12.086<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-12132d8 elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"12132d8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-f82fc2f\" data-id=\"f82fc2f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e9de57 elementor-widget elementor-widget-heading\" data-id=\"2e9de57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Keywords:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c21f70 elementor-widget elementor-widget-text-editor\" data-id=\"9c21f70\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>nanofibrous materials, bio-based polymers, bioactive compounds of plant origin, electrospinning, electrospraying, antimicrobial materials, materials with antitumor activity\u00a0<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>New Electrospun Polymeric Materials Containing Natural Biologically Active Compounds: Preparation and Properties Coordinator: Prof. Nevenka Emanuilova Manolova, DSc Base organization: Institute of Polymers,\u00a0Bulgarian Academy of Sciences Partner organizations: Faculty of Pharmacy &#8211; Medical University \u2013 Sofia Duration: December 2014 \u2013 December 2017 Abstract Novel advanced materials from biocompatible bio-based polymers such as poly(lactic acid), poly(3-hydroxybutyrate) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":6625,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7029","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Electrospun Polymeric Materials Containing Natural Biologically Active Compounds: Preparation and Properties - polymer<\/title>\n<meta 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