{"id":7070,"date":"2023-01-15T01:50:35","date_gmt":"2023-01-15T01:50:35","guid":{"rendered":"https:\/\/polymer.bas.bg\/projects\/national-science-fund\/%d0%bf%d0%be%d0%bb%d1%83%d1%87%d0%b0%d0%b2%d0%b0%d0%bd%d0%b5-%d0%bd%d0%b0-%d0%b8%d0%bd%d0%be%d0%b2%d0%b0%d1%82%d0%b8%d0%b2%d0%bd%d0%b8-%d0%b0%d0%bd%d1%82%d0%b8%d0%bc%d0%b8%d0%ba%d1%80%d0%be%d0%b1\/"},"modified":"2023-07-28T12:26:55","modified_gmt":"2023-07-28T12:26:55","slug":"%d0%bf%d0%be%d0%bb%d1%83%d1%87%d0%b0%d0%b2%d0%b0%d0%bd%d0%b5-%d0%bd%d0%b0-%d0%b8%d0%bd%d0%be%d0%b2%d0%b0%d1%82%d0%b8%d0%b2%d0%bd%d0%b8-%d0%b0%d0%bd%d1%82%d0%b8%d0%bc%d0%b8%d0%ba%d1%80%d0%be%d0%b1","status":"publish","type":"page","link":"https:\/\/polymer.bas.bg\/en\/projects\/national-science-fund\/%d0%bf%d0%be%d0%bb%d1%83%d1%87%d0%b0%d0%b2%d0%b0%d0%bd%d0%b5-%d0%bd%d0%b0-%d0%b8%d0%bd%d0%be%d0%b2%d0%b0%d1%82%d0%b8%d0%b2%d0%bd%d0%b8-%d0%b0%d0%bd%d1%82%d0%b8%d0%bc%d0%b8%d0%ba%d1%80%d0%be%d0%b1\/","title":{"rendered":"Preparation of innovative antimicrobial and antitumor electrospun materials from mucoadhesive and biocompatible polymers and chelating agents from the 8-quinolinol group"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7070\" class=\"elementor elementor-7070 elementor-1850\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-617b4bc elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"617b4bc\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d496f7f\" data-id=\"d496f7f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c6d2dce elementor-widget elementor-widget-image\" data-id=\"c6d2dce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"592\" height=\"120\" src=\"https:\/\/polymer.bas.bg\/wp-content\/uploads\/2022\/10\/fni-logo.png\" class=\"attachment-large size-large wp-image-4521\" alt=\"\" srcset=\"https:\/\/polymer.bas.bg\/wp-content\/uploads\/2022\/10\/fni-logo.png 592w, https:\/\/polymer.bas.bg\/wp-content\/uploads\/2022\/10\/fni-logo-300x61.png 300w\" sizes=\"(max-width: 592px) 100vw, 592px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b000185 elementor-widget elementor-widget-heading\" data-id=\"b000185\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Project Preparation of innovative antimicrobial and antitumor electrospun materials from mucoadhesive and biocompatible polymers and chelating agents from the 8-quinolinol group <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-096ab83 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"096ab83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-be174fa elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"be174fa\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f7ef78b\" data-id=\"f7ef78b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54552b1 elementor-widget elementor-widget-heading\" data-id=\"54552b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Project KP-06-N39\/13<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5568a4 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c5568a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-000c349 elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"000c349\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9390a35\" data-id=\"9390a35\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7f7de4d elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7f7de4d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-9367aaf\" data-id=\"9367aaf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-be3deaa elementor-widget elementor-widget-heading\" data-id=\"be3deaa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Coordinator:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff3f3c4 elementor-widget elementor-widget-text-editor\" data-id=\"ff3f3c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Prof. Nevenka Manolova<br \/><strong><em><span style=\"color: #3375a4;\"><br \/><\/span><\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee2d9eb elementor-widget elementor-widget-heading\" data-id=\"ee2d9eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Base organization:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a21c33 elementor-widget elementor-widget-text-editor\" data-id=\"7a21c33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Institute of Polymers,\u00a0<\/em><em>Bulgarian Academy of Sciences<br \/><br \/><\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a876ca7 elementor-widget elementor-widget-heading\" data-id=\"a876ca7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Partner  organizations:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fea9ce5 elementor-widget elementor-widget-text-editor\" data-id=\"fea9ce5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Institute of Experimental Morphology, Pathology and Anthropology with Museum &#8211; Bulgarian Academy of Sciences<br \/><br \/><\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d32ef90 elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"d32ef90\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f0352fb\" data-id=\"f0352fb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-474dfac elementor-widget elementor-widget-heading\" data-id=\"474dfac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Start:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54a0f5c elementor-widget elementor-widget-text-editor\" data-id=\"54a0f5c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><strong>09 December 2019<\/strong><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c721e5a\" data-id=\"c721e5a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c16f9aa elementor-widget elementor-widget-heading\" data-id=\"c16f9aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Duration:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fa6929f elementor-widget elementor-widget-text-editor\" data-id=\"fa6929f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>36 months<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-664de48 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"664de48\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-088de00\" data-id=\"088de00\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4987f24 elementor-widget elementor-widget-heading\" data-id=\"4987f24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Summary:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-290360d elementor-widget elementor-widget-text-editor\" data-id=\"290360d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The project aims at finding original approaches for the creation of innovative electrospun materials with improved design and purposely tailored properties containing low-molecular-weight compounds (LmCs) with chelating properties and biological activity that are potential candidates for future applications in the biomedical field to fight with some of the causes of bacterial and fungal infections or of cancer diseases. The project is of fundamental character and envisages finding appropriate means for combining the properties of mucoadhesive and biocompatible natural polysaccharides and non-ionogenic water-soluble polymers with those of selected LmCs with chelating properties and antimicrobial and antitumor activity (8-quinolinol derivatives). The structure and the morphology of the innovative materials will be purposely modulated by using the advanced method of electrospinning or its conjunction with electrospraying. Four types of novel micro- and nanofibrous materials will be obtained and characterized: (i) with LmCs incorporated in their bulk, (ii) with LmCs on their surface, and containing LmCs bound ionically (iii) or covalently (iv). The relation between the composition and the design of micro- and nanofibers and the LmCs release profile will be studied in vitro. The metal chelating ability of the fibrous materials will be also studied. In vitro tests will be performed to clarify the relationship between the composition and structure of the innovative fibrous polymer materials and their biological effect against selected pathogenic microorganisms (bacteria and fungi) and against human tumor cell lines that cause refractory and socially significant diseases. The acquired new knowledge will open prospects of tackling this major societal challenge.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Project Preparation of innovative antimicrobial and antitumor electrospun materials from mucoadhesive and biocompatible polymers and chelating agents from the 8-quinolinol group Project KP-06-N39\/13 Coordinator: Prof. Nevenka Manolova Base organization: Institute of Polymers,\u00a0Bulgarian Academy of Sciences Partner organizations: Institute of Experimental Morphology, Pathology and Anthropology with Museum &#8211; Bulgarian Academy of Sciences Start: 09 December 2019 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":6625,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7070","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Preparation of innovative antimicrobial and antitumor electrospun materials from mucoadhesive and biocompatible polymers and chelating agents from the 8-quinolinol group - polymer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/polymer.bas.bg\/en\/projects\/national-science-fund\/\u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u043d\u0435-\u043d\u0430-\u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0438-\u0430\u043d\u0442\u0438\u043c\u0438\u043a\u0440\u043e\u0431\/\" 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